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A new study just published on Feb 2011 in the journal of cancer makes a strong argument for applying hyperbaric oxygenation therapy (HBOT) for those patients who have had either surgery or radiation therapy for brain tumors. The study followed patients who had been treated with HBOT and there was a marked improvement in cognitive [...]

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Healing with Hyperbaric Oxygen therapy

Tuesday, March 10th, 2009

Putting pressure on the healing process

March 10, 2009 By Paul Drewes

KALIHI (KHNL) – When you think of hyperbaric chambers, you probably think of scuba divers with the bends. But nowadays, these chambers are being used for dozens of treatments that have nothing to do with the water, and everything to do with healing. A trip to the oral surgeon was what brought Jane Shannon to the hyperbaric chamber for her first treatment. “I had surgery, and had no need for pain medications, no swelling even with stitches all thru my gums. I was even able to sleep at night,” said the Hawaii Kai resident. But Shannon also discovered something else after her hour long sessions in the chambers. Her hands weren’t as numb as they used to be. “I have multiple sclerosis, I noticed from the first treatment that my fingertips were getting more feeling” Now she make hyperbaric treatment a regular part of her regimen to fight the effects of MS. It is one of the approved uses of hyperbaric therapy but not one that is currently covered by health insurance. So how does it work? During treatment the chambers are pressurized down to what would be 15-45 feet underwater and pure oxygen is pumped in. That allows lots of oxygen to get to wounds and injured areas, speeding the healing process. “It creates the perfect environment for the body to kick start its own healing process,” said Helen McCracken, with the Hyperbaric Medicine Center. Its made a difference for some stroke victims, children with autism, and diabetics with wounds on their extremities. “Often times, this treatment, along with wound care can save limbs,” added McCracken. But this therapy has remained largely isolated from conventional medicine. And even a believer like Shannon isn’t holding her breath for others to realize how hyperbaric treatment has made a difference in her life. “They have no idea what it is, I would like to see people educated on what this type of therapy can do,” said Shannon. Patients typically will have between 20-40 hours of treatments, depending on the injury or condition. Only about 14 of those conditions are currently covered by insurance. For others, patients pay between $150-195 an hour for time in the hyperbaric chamber

Hyperbaric Oxygen Treats A Variety of Conditions

Monday, August 18th, 2008

Hyperbaric treatments said to cure, help treat a myriad of ills

08-03-2007 06:07; by Rebecca L. Sandlin

Mark Merrell was at his wits’ end. His young daughter, Maddie, was diagnosed as profoundly autistic. “We tried a number of therapies and been to a number of different places, and my kid’s pretty sick, and you accept that, and there’s just nothing anybody can do for her,” Merrell explained. “So we basically had to become our own advocates.” After investigating alternative therapies for his child, Merrell wound up in Florida, where he learned that hyperbaric medicine is being used to treat autism. “Many people like myself who are all right here in this Fishers-Carmel-Zionsville area, many of our doctors are not in Indiana,” he said. “Our backs are against the wall. We need help, and we can’t wait another six months for this study or another year for that drug. We need help now.” After using the hyperbaric chamber about 4 to 5 days per week, Merrell said the results of the treatments on Maddie have been astounding. “We can go out in public with our daughter now and nobody notices us … nobody looks at us. The change has been amazing,” he said. Merrell believes in the treatments so much he not only installed a hyperbaric chamber in his home, but also left his job as a police officer to open Oxyspa, a salon located at 11559 Cumberland Road in Fishers that features hyperbaric oxygen treatments. Oxsyspa is one a few locations in the Midwest that offers the treatments, using an FDA-approved hyperbaric chamber. When hyperbaric chambers were first installed in some Indianapolis-area hospitals, they were mainly used for treating burn victims or those who had carbon monoxide poisoning. Hospital chambers use a much greater pressure than what can be found at Oxyspa, but Merrell said the lighter pressure, non-invasive and non-pharmaceutical treatments are beginning to come into their own as an alternative therapy. David Darbro, M.D., the medical director who provides medical oversight at Oxyspa, became a believer in hyperbaric treatments after he changed roles and became a patient when he suffered a stroke three years ago. The stroke affected his speech. “You would not have been able to have understood me, were we speaking three years ago,” he said. Darbro drew a picture of a hyperbaric chamber to get his wishes across. After undergoing the pressurized oxygen treatments, he no longer takes medications and has no difficulty communicating. It just made sense, that when you check people’s oxygen, especially with chronic degenerative disorders, they seem to be low on oxygen and didn’t have any energy,” he said. Darbro said mild hyperbaric therapy is indicated in treatments of several illnesses and conditions, including migraine, heart problems and diabetes. It is also used to treat wounds, sports injuries, osteomyelitis, skin grafts, traumatic brain injury, cerebral palsy and multiple sclerosis. Darbro, who specializes in holistic medicine, said the treatments benefit the patient by helping to increase the body’s ability to absorb oxygen. “Your breathing is the key to opening the door to energy,” he said. “The idea of pressurized oxygen – putting oxygen under pressure – is the key, because it’s putting more oxygen in the fluid – the plasma – in between the red blood cells.” There are only 13 FDA-approved uses of hyperbaric treatments, so insurance may not cover treatments for other medical conditions. Articles of studies and other findings about the treatments have appeared in the Journal of American Medical Association. One article, published in 1990, calls hyperbaric treatments a controversial therapy. Another article, published in 2004, suggests hyperbaric oxygen therapy improves survival and limb salvage of patients with necrotizing soft tissue infections. A session at Oxyspa costs $80 for a treatment lasting around an hour, with packages available. A doctor’s prescription or order is mandatory before a client can begin therapy. Merrell said physicians from several disciplines including neurologists have referred their patients to the spa for treatments. He added the spa also follows FDA regulations by charting each client’s progress and condition during treatment. Cindy Beuoy, of Indianapolis, has been using the chamber since February and has noticed some benefits from regular visits. “I try to stay as healthy as I can. I’m a real pro-active person on health,” she said. “I found that, using the chamber, it helps me to sleep better. I exercise – I do strength training exercise three times a week and it helps my muscles recover faster from the exercise. I just feel my overall vitality is greater.”

NEW STUDY–Application of HBOT Increases Brain Antioxidant Levels

Sunday, May 11th, 2008

Hyperbaric oxygen preconditioning induces tolerance against brain ischemia-reperfusion injury by upregulation of antioxidant enzymes in rats.

Brain Res. 2008 May

Li J, Liu W, Ding S, Xu W, Guan Y, Zhang JH, Sun X.

Department of Neurology, Changhai Hospital,174 Changhai Road, Shanghai 200433, PR China.

The present study examined the hypothesis that cerebral ischemic tolerance induced by hyperbaric oxygen preconditioning (HBO-PC) is associated with an increase of antioxidant enzyme activity. Male Sprague-Dawley rats (250-280 g, n=74) were divided into sham, middle cerebral artery occlusion (MCAO) for 90 min, and MCAO plus HBO-PC groups. HBO-PC was conducted four times by given 100% oxygen at 2.5 atmosphere absolute (ATA), for 1 h at every 12 h interval for 2 days. At 24 h after the last HBO-PC, MCAO was performed and at 24 h after MCAO, neurological function and Nissl Staining were performed to evaluate the effect of HBO-PC. Malondialdehyde (MDA) content, activity of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-px) sampled from the hippocampus, ischemic penumbra or core of cortex were measured. HBO-PC decreased mortality rate, improved neurological recovery, lessened neuronal injury, reduced the level of MDA and increased the antioxidant activity of CAT and SOD. These observations demonstrated that an upregulation of the antioxidant enzyme activity by HBO preconditioning plays an important role in the generation of tolerance against brain ischemia-reperfusion injury.

Hyperbaric Oxygen Revolutionizing Medicine

Sunday, April 6th, 2008

Hyperbaric Oxygen Therapy revolutionizing medical field

April 6th 2008 Gino Troiani

Hyperbaric oxygen treatment (HBOT) is the medical use of pure oxygen at higher than atmospheric pressure. Its concept is simple. Increased pressure enables higher amounts of oxygen to enter the blood stream, therefore, jumpstarting the healing process. Red blood cells are the most common type of blood cell in the human body. They are responsible for delivering oxygen from the lungs to the rest of the body via the blood stream. In many cases, increased oxygen can be key to many recovery processes. According to Michael Neumeister, M.D. in an article published in 2005, the first hyperbaric chambers date back to the late 1600s. These chambers were used in the treatment of ailments such as inflammations, scurvy, arthritis, and rickets, but due to a lack of technology, minimal effectiveness was recorded. Still, throughout the years, many scientists kept playing with the idea, hoping one day for a medical breakthrough. That breakthrough came in the early 1900s when Dr. Orville Cunningham discovered that patients with cardio vascular disorders improved significantly when moved to lower altitudes with denser air. With this finding, Cunningham took it upon himself to design a modern electric hyperbaric chamber, standing eight feet in diameter and thirty feet long. Cunningham used his chamber to treat multiple patients who suffered from the Spanish flu, and experienced tremendous results. However, because of the great depression in the 1930s, he was no longer able to continue his research. In the 1970s, similar chambers were designed and used by the armed forces to treat many diving and decompression illnesses such as the bends and caisson disease, suffered by Navy and Air force soldiers.  Today these illnesses only represent three percent of all of the total uses for HBOT. In the last 35 years, curiosity has led many doctors and scientists to conducted experiments on the effectiveness of hyperbaric therapy. Many studies have proven to show significant recovery increases in head injuries, myasthenia gravis, myocardial infarction, free skin grafts, sudden deafness, burns, glaucoma, leg ulcers, heart attacks, strokes, cerebral palsy, and carbon monoxide poisoning. HBOT is also commonly used to help treat autism

New Hyperbaric Center Opens with Focus on Chronic Health Conditions

Monday, March 31st, 2008

Hyperbaric therapy coming to Austin

Monday, March 31, 2008

Someday soon, Haelen Hyperbarics will reach across the nation and its hyperbaric oxygen therapy will be an everyday part of the nation’s health care, if the management’s vision comes true.  The Hilton Head Island, S.C.-based company already has its hyperbaric chambers set up at two island health-care centers. The company plans to open centers in Austin; Raleigh, N.C.; West Palm Beach, Fla.; Savannah, Ga.; and Memphis, Tenn., by the end of the year, said Andrew Kolb, company president.  A hyperbaric chamber is an airtight chamber that patients lie in for about an hour, breathing pure oxygen in a pressurized atmosphere. The extra oxygen helps speed recovery on everything from broken bones to neurological disorders, Kolb said.  Hospitals also have the chambers, but they are used typically for only a few things covered by insurance, such as wound recovery or tissue damage from radiation. At Haelen’s Hilton Head locations, services are elective, meaning they’re not covered by insurance and patients pay out of pocket. Popular reasons for using the facilities include treatment for chronic pain from conditions including rheumatoid arthritis, sports injuries and recovery from cosmetic surgery, Kolb said.

Study–HBOT Improves Penumbral Brain Oxygenation for Stroke Victims

Tuesday, March 11th, 2008

Hyperbaric oxygen reduces tissue hypoxia and hypoxia-inducible factor-1 alpha expression in focal cerebral ischemia.

Stroke. 2008 Mar

Sun L, Marti HH, Veltkamp R.

Department of Neurology, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany.

BACKGROUND AND PURPOSE: The usefulness of hyperbaric oxygen (HBO) and normobaric hyperoxia in acute ischemic stroke is being reexplored because both improve outcome in experimental cerebral ischemia. However, even the basic mechanisms underlying oxygen therapy are poorly understood. We investigated the effect of both oxygen therapies on tissue hypoxia and on the transcription factor hypoxia-inducible factor-1 alpha. METHODS: Mice were subjected to filament-induced middle cerebral artery occlusion for 2 hours. Twenty-five minutes after filament introduction, mice breathed normobaric air, normobaric 100% O(2) (normobaric hyperoxia), or 100% O(2) at 3 ata (HBO) for 95 minutes. Hypoxic regions were mapped on tissue sections after preischemic infusion of the in vivo hypoxia marker EF-5. Hypoxia-inducible factor-1 alpha protein was measured after 2-hour middle cerebral artery occlusion using immunofluorescence and immunoblotting. Vascular endothelial growth factor expression was analyzed using in situ mRNA hybridization. RESULTS: Severity of ischemia did not differ among groups. HBO (35.2+/-10.4 mm(2)) significantly reduced the area of EF-5-stained hypoxic regions in focal cerebral ischemia compared with normobaric hyperoxia (46.4+/-11.2 mm(2)) and air (49.1+/-8 mm(2), P<0.05, analysis of variance). Topographically, EF-5 fluorescence was decreased in medial striatum and in cortical ischemic border areas. Immunohistochemistry and immunoblotting revealed lower hypoxia-inducible factor-1 alpha protein in the ischemic hemisphere of HBO-treated mice. Moreover, mRNA in situ hybridization showed lower expression of vascular endothelial growth factor in HBO and normobaric hyperoxia groups. CONCLUSIONS: Measurement of extrinsic and intrinsic markers of hypoxia revealed that HBO improves penumbral oxygenation in focal ischemia. Modification of the transcription factor hypoxia-inducible factor-1 alpha and its downstream targets may be involved in effects of HBO.

Study–HBOT shows promise for Autism

Tuesday, December 4th, 2007

Hyperbaric oxygen therapy might improve certain pathophysiological

findings in autism.

Med Hypotheses. 2007;68(6):1208-27. Epub 2006 Dec 4.

Rossignol DA.

University of Virginia, Department of Family Medicine, P.O. Box 800729, Charlottesville, VA 22908, USA. dlross7@hotmail.com

Autism is a neurodevelopmental disorder currently affecting as many as 1 out of 166 children in the United States. Numerous studies of autistic individuals have revealed evidence of cerebral hypoperfusion, neuroinflammation and gastrointestinal inflammation, immune dysregulation, oxidative stress, relative mitochondrial dysfunction, neurotransmitter abnormalities, impaired detoxification of toxins, dysbiosis, and impaired production of porphyrins. Many of these findings have been correlated with core autistic symptoms. For example, cerebral hypoperfusion in autistic children has been correlated with repetitive, self-stimulatory and stereotypical behaviors, and impairments in communication, sensory perception, and social interaction. Hyperbaric oxygen therapy (HBOT) might be able to improve each of these problems in autistic individuals. Specifically, HBOT has been used with clinical success in several cerebral hypoperfusion conditions and can compensate for decreased blood flow by increasing the oxygen content of plasma and body tissues. HBOT has been reported to possess strong anti-inflammatory properties and has been shown to improve immune function. There is evidence that oxidative stress can be reduced with HBOT through the upregulation of antioxidant enzymes. HBOT can also increase the function and production of mitochondria and improve neurotransmitter abnormalities. In addition, HBOT upregulates enzymes that can help with detoxification problems specifically found in autistic children. Dysbiosis is common in autistic children and HBOT can improve this. Impaired production of porphyrins in autistic children might affect the production of heme, and HBOT might help overcome the effects of this problem. Finally, HBOT has been shown to mobilize stem cells from the bone marrow to the systemic circulation. Recent studies in humans have shown that stem cells can enter the brain and form new neurons, astrocytes, and microglia. It is expected that amelioration of these underlying pathophysiological problems through the use of HBOT will lead to improvements in autistic symptoms. Several studies on the use of HBOT in autistic children are currently underway and early results are promising.

Study–Confirmation of New Brain Cells from HBOT

Tuesday, October 16th, 2007

Proliferation of neural stem cells correlates with Wnt-3 protein in hypoxic-ischemic neonate rats after hyperbaric oxygen therapy.

Neuroreport. 2007 Oct 29;18(16):1753-1756.

Wang XL, Yang YJ, Xie M, Yu XH, Liu CT, Wang X.

Department of Pediatrics, Xiang Ya Hospital, Central South University, Changsha, PR China.

Hyperbaric oxygen therapy promoted brain cell proliferation. Wnt-3 is closely associated with the proliferation of neural stem cells. We examined whether hyperbaric oxygen promoted neural stem cells to proliferate and its correlation with Wnt-3 protein in hypoxic-ischemic neonate rats. Hyperbaric oxygen therapy was administered 3 h after hypoxia ischemia daily for 7 days. The proliferating stem cells and Wnt-3 protein were examined dynamically in the subventricular zone. Results showed that stem cells proliferated and peaked 7 days after hyperbaric oxygen therapy. Wnt-3 protein increased to the higher levels 3 days after therapy. Linear regression analysis showed that nestin protein correlated with Wnt-3 protein. We propose that hyperbaric oxygen treatment promote stem cells to proliferate, which is correlated with Wnt-3 protein.

Hyperbaric oxygen therapy becomes mainstream medicine

Friday, October 5th, 2007

Hyperbaric oxygen therapy becomes mainstream medicine

Oct. 5th 2007

By Kyle Alspach, Enterprise staff writer BROCKTON—

Once viewed with skepticism, hyperbaric oxygen therapy is becoming a mainstream medical practice and getting plenty of interest in southeastern Massachusetts. Caritas Good Samaritan Medical Center in Brockton plans to open a hyperbaric center next summer in Stoughton, and two facilities are already operating in the region. Oxygen has long been accepted as a treatment for smoke inhalation and carbon monoxide poisoning. But hyperbaric oxygen therapy, which involves breathing pure oxygen in a high-pressure environment, is increasingly being used to heal chronic wounds, reverse damage from radiation therapy and even treat conditions like autism and cerebral palsy.It’s just now becoming more accepted and widely prescribed. That’s why more facilities are getting chambers,” said Dr. Grace Doherty, medical director at the Hyperbaric Oxygen Treatment Center in Randolph. That center opened in 2001 and was one of the first in Massachusetts. Morton Hospital and Medical Center in Taunton began offering hyperbaric treatment last fall, and Good Samaritan’s center is slated to open in June. During the hyperbaric treatment, patients breathe 100 percent oxygen — five times the normal amount — for several hours inside a chamber with a pressure greater than sea level. The pressure forces the oxygen into the bloodstream, killing bacteria and stimulating the growth of new blood vessels. The effect is a much speedier healing process, said Dr. Joseph Tito, medical director of the Center for Wound Healing at Morton Hospital, which has three hyperbaric chambers. Many of those treated with hyperbaric chambers in Taunton suffer from chronic wounds related to diabetes, which are normally difficult to heal and can end up requiring amputation. Hyperbarics are also helping counteract the effects of chemotherapy and radiation treatments, Tito said. The patient remains conscious during the treatment and often watches a movie or reads a book. The experience is painless, but patients sometimes feel discomfort in their ears due to the pressure. Patients often need between 10 and 40 treatments to show major improvement. But, Tito says, “it clearly does work.” And it’s working for a surprising range of other conditions, according to some practitioners. At the Randolph center, neurological disorders such as autism and cerebral palsy are both being treated successfully with hyperbaric chambers, said Doherty, the director. In the case of autism — a rapidly growing behavioral disorder — effective treatments have been hard to find. Yet after receiving hyperbaric therapy, many autistic children are calmer, more talkative and show improved cognitive skills, according to Doherty. “Nobody really knows why it works with autism,” she said. “But it’s becoming more and more accepted by autism doctors.” There are no scientific studies to support the use of hyperbaric chambers for autism, cerebral palsy and many other conditions, critics point out. And the Food and Drug Administration, citing information from the Undersea and Hyperbaric Medical Society, only recognizes hyperbaric chambers as effective for treating injuries, wounds and infections. But even these treatments are fairly cutting edge. The Massachusetts Eye and Ear Infirmary in Boston opened the state’s first hyperbaric oxygen center in 1995. Millie Doten, a hyperbaric nurse at the hospital, said only about five or six hospitals in the state have opened hyperbaric centers since then. Caritas Good Samaritan would be the latest. The hospital plans to offer three hyperbaric chambers and a staff of four to five doctors at its new Wound Care Center, to be located at the former Goddard Memorial Hospital on Sumner Street in Stoughton. “We’ve seen there’s a need for this kind of wound care in the immediate area,” said Kevin Griffin, director of respiratory care at Good Samaritan. Griffin said Medicare and some private insurance companies cover hyperbaric oxygen therapy for certain, but not all, conditions. Yet all indications are that the treatment is only going to become more common in the future, experts say. “It’s growing in leaps and bounds,” Griffin said.

  • Hyperbaric oxygen therapy treats chronic wounds, radiation-chemotherapy damage, autism, cerebral palsy and other conditions.
  • Morton Hospital in Taunton and the Hyperbaric Oxygen Treatment Center in Randolph have hyperbaric oxygen chambers.

Caritas Good Samaritan Medical Center in Brockton plans to open a hyperbaric center next summer in Stoughton.